Deputy business editor John Fox-Clinch is leaving to go to a Bristol financial adviser in a PR role.
Deputy news editor Ruth Wood will start her maternity leave at the end of the month, and chief reporter Chris Roe will leave in January to move to London.
At present, there has been no announcement for replacements for Ruth, Chris and John.
Sarah Pritchard-Williams has become the WDP's internet editor responsible for content on www.westpress.co.uk. Rachel Sugden replaces her as magazine editor.
Dan Regan has been appointed picture editor to replace Rob Browne who left a few weeks ago.
The Western Daily Press is published Monday to Saturday mornings and covers Gloucestershire, Bristol, Bath, Wiltshire, Herefordshire, North Devon, Dorset and Somerset.